Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions

المؤلف

Martinez-Martin, Nadia

المصدر

Journal of Immunology Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-02-22

دولة النشر

مصر

عدد الصفحات

18

التخصصات الرئيسية

الأحياء

الملخص EN

Pathogens have evolved unique mechanisms to breach the cell surface barrier and manipulate the host immune response to establish a productive infection.

Proteins exposed to the extracellular environment, both cell surface-expressed receptors and secreted proteins, are essential targets for initial invasion and play key roles in pathogen recognition and subsequent immunoregulatory processes.

The identification of the host and pathogen extracellular molecules and their interaction networks is fundamental to understanding tissue tropism and pathogenesis and to inform the development of therapeutic strategies.

Nevertheless, the characterization of the proteins that function in the host-pathogen interface has been challenging, largely due to the technical challenges associated with detection of extracellular protein interactions.

This review discusses available technologies for the high throughput study of extracellular protein interactions between pathogens and their hosts, with a focus on mammalian viruses and bacteria.

Emerging work illustrates a rich landscape for extracellular host-pathogen interaction and points towards the evolution of multifunctional pathogen-encoded proteins.

Further development and application of technologies for genome-wide identification of extracellular protein interactions will be important in deciphering functional host-pathogen interaction networks, laying the foundation for development of novel therapeutics.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Martinez-Martin, Nadia. 2017. Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1181606

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Martinez-Martin, Nadia. Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions. Journal of Immunology Research No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1181606

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Martinez-Martin, Nadia. Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1181606

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1181606