Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions
Author
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-22
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Pathogens have evolved unique mechanisms to breach the cell surface barrier and manipulate the host immune response to establish a productive infection.
Proteins exposed to the extracellular environment, both cell surface-expressed receptors and secreted proteins, are essential targets for initial invasion and play key roles in pathogen recognition and subsequent immunoregulatory processes.
The identification of the host and pathogen extracellular molecules and their interaction networks is fundamental to understanding tissue tropism and pathogenesis and to inform the development of therapeutic strategies.
Nevertheless, the characterization of the proteins that function in the host-pathogen interface has been challenging, largely due to the technical challenges associated with detection of extracellular protein interactions.
This review discusses available technologies for the high throughput study of extracellular protein interactions between pathogens and their hosts, with a focus on mammalian viruses and bacteria.
Emerging work illustrates a rich landscape for extracellular host-pathogen interaction and points towards the evolution of multifunctional pathogen-encoded proteins.
Further development and application of technologies for genome-wide identification of extracellular protein interactions will be important in deciphering functional host-pathogen interaction networks, laying the foundation for development of novel therapeutics.
American Psychological Association (APA)
Martinez-Martin, Nadia. 2017. Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1181606
Modern Language Association (MLA)
Martinez-Martin, Nadia. Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions. Journal of Immunology Research No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1181606
American Medical Association (AMA)
Martinez-Martin, Nadia. Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1181606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181606