Antitumor Effect of KML-B-Treated Dendritic Cells via Induction of Lymphocyte Activation

المؤلفون المشاركون

Kim, Jong-Bae
Kim, Jong-Jin
Choi, Jina
Kang, Kyung-Yun
Yee, Sung-Tae
Hwang, Yun-Ho
Lee, Sung-Ju

المصدر

Journal of Immunology Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-05-29

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Lectins are carbohydrate-binding proteins with various biological activities, such as antitumor and immunomodulatory effects.

Although lectins have various biological activities, they are still limited by cytotoxicity in normal cells.

To overcome this problem, we used the noncytotoxic part of Korean mistletoe lectin B-chain (KML-B) to induce maturation of dendritic cells (DCs).

A previous study reported that KML-B induces DC maturation by triggering TLR-4, including expression of costimulatory molecules (CD40, CD80, and CD86), MHC II, and secretion of cytokines in DCs.

Additionally, matured DCs by KML-B induced T helper (Th) cell activation and differentiation toward Th1 cells.

However, the interaction of KML-B-treated DCs with CD8+ T cells is still poorly understood.

In this study, we confirmed the ability of matured DCs by KML-B to stimulate cytotoxic T cells using OT-1 mouse-derived CD8+ T cells.

KML-B induced MHC I expression in DCs, stimulation of CD8+ T cell activation and proliferation, and IFN-γ secretion.

Moreover, tumor sizes were reduced by KML-B treatment during vaccination of OVA257−264-pulsed DCs.

Here, we confirmed induction of CD8+ T cell activation and the antitumor effect of KML-B treatment in DCs.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kim, Jong-Jin& Hwang, Yun-Ho& Kang, Kyung-Yun& Lee, Sung-Ju& Kim, Jong-Bae& Choi, Jina…[et al.]. 2017. Antitumor Effect of KML-B-Treated Dendritic Cells via Induction of Lymphocyte Activation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181620

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kim, Jong-Jin…[et al.]. Antitumor Effect of KML-B-Treated Dendritic Cells via Induction of Lymphocyte Activation. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181620

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kim, Jong-Jin& Hwang, Yun-Ho& Kang, Kyung-Yun& Lee, Sung-Ju& Kim, Jong-Bae& Choi, Jina…[et al.]. Antitumor Effect of KML-B-Treated Dendritic Cells via Induction of Lymphocyte Activation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181620

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1181620