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Antitumor Effect of KML-B-Treated Dendritic Cells via Induction of Lymphocyte Activation
Joint Authors
Kim, Jong-Bae
Kim, Jong-Jin
Choi, Jina
Kang, Kyung-Yun
Yee, Sung-Tae
Hwang, Yun-Ho
Lee, Sung-Ju
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lectins are carbohydrate-binding proteins with various biological activities, such as antitumor and immunomodulatory effects.
Although lectins have various biological activities, they are still limited by cytotoxicity in normal cells.
To overcome this problem, we used the noncytotoxic part of Korean mistletoe lectin B-chain (KML-B) to induce maturation of dendritic cells (DCs).
A previous study reported that KML-B induces DC maturation by triggering TLR-4, including expression of costimulatory molecules (CD40, CD80, and CD86), MHC II, and secretion of cytokines in DCs.
Additionally, matured DCs by KML-B induced T helper (Th) cell activation and differentiation toward Th1 cells.
However, the interaction of KML-B-treated DCs with CD8+ T cells is still poorly understood.
In this study, we confirmed the ability of matured DCs by KML-B to stimulate cytotoxic T cells using OT-1 mouse-derived CD8+ T cells.
KML-B induced MHC I expression in DCs, stimulation of CD8+ T cell activation and proliferation, and IFN-γ secretion.
Moreover, tumor sizes were reduced by KML-B treatment during vaccination of OVA257−264-pulsed DCs.
Here, we confirmed induction of CD8+ T cell activation and the antitumor effect of KML-B treatment in DCs.
American Psychological Association (APA)
Kim, Jong-Jin& Hwang, Yun-Ho& Kang, Kyung-Yun& Lee, Sung-Ju& Kim, Jong-Bae& Choi, Jina…[et al.]. 2017. Antitumor Effect of KML-B-Treated Dendritic Cells via Induction of Lymphocyte Activation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181620
Modern Language Association (MLA)
Kim, Jong-Jin…[et al.]. Antitumor Effect of KML-B-Treated Dendritic Cells via Induction of Lymphocyte Activation. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181620
American Medical Association (AMA)
Kim, Jong-Jin& Hwang, Yun-Ho& Kang, Kyung-Yun& Lee, Sung-Ju& Kim, Jong-Bae& Choi, Jina…[et al.]. Antitumor Effect of KML-B-Treated Dendritic Cells via Induction of Lymphocyte Activation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181620