Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?

المؤلفون المشاركون

McGregor, Christopher G. A.
Byrne, Guerard W.

المصدر

Journal of Immunology Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-11-07

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts.

Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney XTx.

Advances in donor genetic modification (B4GALNT2 and CMAH mutations) with proven Gal-deficient donors expressing human complement regulatory protein(s) have also accelerated, reducing donor pig organ antigenicity.

These advances can now be combined and tested in life-supporting orthotopic preclinical studies in nonhuman primates and immunologically appropriate models confirming their efficacy and safety for a clinical CXTx program.

Preclinical studies should also allow for organ rejection to develop xenospecific assays and therapies to reverse rejection.

The complexity of future clinical CXTx presents a substantial and unique set of regulatory challenges which must be addressed to avoid delay; however, dependent on these prospective life-supporting preclinical studies in NHPs, it appears that the scientific path forward is well defined and the era of clinical CXTx is approaching.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

McGregor, Christopher G. A.& Byrne, Guerard W.. 2017. Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181626

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

McGregor, Christopher G. A.& Byrne, Guerard W.. Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?. Journal of Immunology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1181626

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

McGregor, Christopher G. A.& Byrne, Guerard W.. Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181626

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1181626