Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?
Joint Authors
McGregor, Christopher G. A.
Byrne, Guerard W.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts.
Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney XTx.
Advances in donor genetic modification (B4GALNT2 and CMAH mutations) with proven Gal-deficient donors expressing human complement regulatory protein(s) have also accelerated, reducing donor pig organ antigenicity.
These advances can now be combined and tested in life-supporting orthotopic preclinical studies in nonhuman primates and immunologically appropriate models confirming their efficacy and safety for a clinical CXTx program.
Preclinical studies should also allow for organ rejection to develop xenospecific assays and therapies to reverse rejection.
The complexity of future clinical CXTx presents a substantial and unique set of regulatory challenges which must be addressed to avoid delay; however, dependent on these prospective life-supporting preclinical studies in NHPs, it appears that the scientific path forward is well defined and the era of clinical CXTx is approaching.
American Psychological Association (APA)
McGregor, Christopher G. A.& Byrne, Guerard W.. 2017. Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181626
Modern Language Association (MLA)
McGregor, Christopher G. A.& Byrne, Guerard W.. Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?. Journal of Immunology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1181626
American Medical Association (AMA)
McGregor, Christopher G. A.& Byrne, Guerard W.. Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181626