Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis
المؤلفون المشاركون
Cen, Xiaomin
Yin, Geng
Xie, Qi-bing
Wang, Ying
Yang, Yuan
Yang, Min
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Polymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes.
However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis.
The mechanistic target of rapamycin (mTOR) signaling is the central regulator of metabolism and inflammation in mammalian cells.
Based on previous studies, we proposed that mTOR signaling may control inflammatory reactions via lipid metabolism.
In this study, we aim to figure out the role of mTOR signaling in the development of polymyositis and identify novel biomarkers for the detection and therapy of polymyositis.
After screening and validation, we found that palmitoleic acid, a monounsaturated fatty acid, is highly regulated by mTOR signaling.
Inhibition of mTORC1 activity decreases palmitoleic acid level.
Moreover, mTORC1 regulates the level of palmitoleic acid by controlling its de novo synthesis.
Importantly, increased palmitoleic acid has been proven to be a marker of polymyositis.
Our work identifies palmitoleic acid in peripheral blood mononuclear cells (PBMC) as a biomarker of polymyositis and offers new targets to the clinical therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yin, Geng& Wang, Ying& Cen, Xiaomin& Yang, Yuan& Yang, Min& Xie, Qi-bing. 2017. Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181700
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yin, Geng…[et al.]. Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181700
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yin, Geng& Wang, Ying& Cen, Xiaomin& Yang, Yuan& Yang, Min& Xie, Qi-bing. Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181700
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181700
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر