Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis
Joint Authors
Cen, Xiaomin
Yin, Geng
Xie, Qi-bing
Wang, Ying
Yang, Yuan
Yang, Min
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Polymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes.
However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis.
The mechanistic target of rapamycin (mTOR) signaling is the central regulator of metabolism and inflammation in mammalian cells.
Based on previous studies, we proposed that mTOR signaling may control inflammatory reactions via lipid metabolism.
In this study, we aim to figure out the role of mTOR signaling in the development of polymyositis and identify novel biomarkers for the detection and therapy of polymyositis.
After screening and validation, we found that palmitoleic acid, a monounsaturated fatty acid, is highly regulated by mTOR signaling.
Inhibition of mTORC1 activity decreases palmitoleic acid level.
Moreover, mTORC1 regulates the level of palmitoleic acid by controlling its de novo synthesis.
Importantly, increased palmitoleic acid has been proven to be a marker of polymyositis.
Our work identifies palmitoleic acid in peripheral blood mononuclear cells (PBMC) as a biomarker of polymyositis and offers new targets to the clinical therapy.
American Psychological Association (APA)
Yin, Geng& Wang, Ying& Cen, Xiaomin& Yang, Yuan& Yang, Min& Xie, Qi-bing. 2017. Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181700
Modern Language Association (MLA)
Yin, Geng…[et al.]. Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181700
American Medical Association (AMA)
Yin, Geng& Wang, Ying& Cen, Xiaomin& Yang, Yuan& Yang, Min& Xie, Qi-bing. Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181700