Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome
المؤلفون المشاركون
Sun, Xiaolin
Li, Zhanguo
He, Jing
Liu, Xu
Gan, Yuzhou
Zhao, Xiaozhen
Li, Yun
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Th17 related immune response is pathogenic in primary Sjögren’s syndrome (pSS).
However, the role of IL-17F, one potent inflammatory member of IL-17 family cytokines in pSS, has not been specifically defined.
We recruited one hundred and nine pSS patients and forty-two healthy controls and their serum levels of IL-17A and IL-17F were determined by multiplex cytokine assays.
White blood cell, red blood cell, neutrophil, lymphocyte, IgM, IgG, C3, C4, RF, ANA, anti-SSA antibody, and anti-SSB antibody were measured by standard laboratory techniques.
EULAR Sjögren’s syndrome disease activity index (ESSDAI) score was also evaluated accordingly.
We found that IL-17F was significantly increased in pSS patients.
Elevated levels of IL-17F were associated with increased IgG and IgM, higher titers of ANA and anti-SSA antibodies, and reduction of C3 and C4.
Patients with higher disease activity also showed higher serum IL-17F levels.
However, serum IL-17A was only increased in patients with longer disease duration and showed few correlation with clinical and laboratory features in pSS patients.
In conclusion, IL-17F was correlated with increased autoantibody levels and disease activity in pSS and is more clinically relevant than IL-17A.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gan, Yuzhou& Zhao, Xiaozhen& He, Jing& Liu, Xu& Li, Yun& Sun, Xiaolin…[et al.]. 2017. Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181857
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gan, Yuzhou…[et al.]. Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1181857
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gan, Yuzhou& Zhao, Xiaozhen& He, Jing& Liu, Xu& Li, Yun& Sun, Xiaolin…[et al.]. Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181857
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181857
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر