Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome
Joint Authors
Sun, Xiaolin
Li, Zhanguo
He, Jing
Liu, Xu
Gan, Yuzhou
Zhao, Xiaozhen
Li, Yun
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Th17 related immune response is pathogenic in primary Sjögren’s syndrome (pSS).
However, the role of IL-17F, one potent inflammatory member of IL-17 family cytokines in pSS, has not been specifically defined.
We recruited one hundred and nine pSS patients and forty-two healthy controls and their serum levels of IL-17A and IL-17F were determined by multiplex cytokine assays.
White blood cell, red blood cell, neutrophil, lymphocyte, IgM, IgG, C3, C4, RF, ANA, anti-SSA antibody, and anti-SSB antibody were measured by standard laboratory techniques.
EULAR Sjögren’s syndrome disease activity index (ESSDAI) score was also evaluated accordingly.
We found that IL-17F was significantly increased in pSS patients.
Elevated levels of IL-17F were associated with increased IgG and IgM, higher titers of ANA and anti-SSA antibodies, and reduction of C3 and C4.
Patients with higher disease activity also showed higher serum IL-17F levels.
However, serum IL-17A was only increased in patients with longer disease duration and showed few correlation with clinical and laboratory features in pSS patients.
In conclusion, IL-17F was correlated with increased autoantibody levels and disease activity in pSS and is more clinically relevant than IL-17A.
American Psychological Association (APA)
Gan, Yuzhou& Zhao, Xiaozhen& He, Jing& Liu, Xu& Li, Yun& Sun, Xiaolin…[et al.]. 2017. Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181857
Modern Language Association (MLA)
Gan, Yuzhou…[et al.]. Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1181857
American Medical Association (AMA)
Gan, Yuzhou& Zhao, Xiaozhen& He, Jing& Liu, Xu& Li, Yun& Sun, Xiaolin…[et al.]. Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181857