Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke
المؤلفون المشاركون
Schulze, Juliane
Vogelgesang, Antje
Ruhnau, Johanna
Dressel, Alexander
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Immune cells can significantly predict and affect the clinical outcome of stroke.
In particular, the neutrophil-to-lymphocyte ratio was shown to predict hemorrhagic transformation and the clinical outcome of stroke; however, the immunological mechanisms underlying these effects are poorly understood.
Neutrophils are the first cells to invade injured tissue following focal brain ischemia.
In these conditions, their proinflammatory properties enhance tissue damage and may promote ischemic incidences by inducing thrombus formation.
Therefore, they constitute a potential target for therapeutic approaches and prevention of stroke.
Indeed, in animal models of focal brain ischemia, neutrophils have been targeted with successful results.
However, even in brain lesions, neutrophils also exert beneficial effects, because they are involved in triggering immunological removal of cell debris.
Furthermore, intact neutrophil function is essential for maintaining immunological defense against bacterial infections.
Several studies have demonstrated that stroke-derived neutrophils displayed impaired bacterial defense capacity.
Because infections are known to impair the clinical course of stroke, therapeutic interventions that target neutrophils should preserve or even restore their function outside the central nervous system (CNS).
This complex situation requires well-tailored therapeutic approaches that can effectively tackle immune cell invasion in the brain but avoid increasing poststroke infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ruhnau, Johanna& Schulze, Juliane& Dressel, Alexander& Vogelgesang, Antje. 2017. Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181897
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ruhnau, Johanna…[et al.]. Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181897
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ruhnau, Johanna& Schulze, Juliane& Dressel, Alexander& Vogelgesang, Antje. Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181897
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181897
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر