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Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke
Joint Authors
Schulze, Juliane
Vogelgesang, Antje
Ruhnau, Johanna
Dressel, Alexander
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Immune cells can significantly predict and affect the clinical outcome of stroke.
In particular, the neutrophil-to-lymphocyte ratio was shown to predict hemorrhagic transformation and the clinical outcome of stroke; however, the immunological mechanisms underlying these effects are poorly understood.
Neutrophils are the first cells to invade injured tissue following focal brain ischemia.
In these conditions, their proinflammatory properties enhance tissue damage and may promote ischemic incidences by inducing thrombus formation.
Therefore, they constitute a potential target for therapeutic approaches and prevention of stroke.
Indeed, in animal models of focal brain ischemia, neutrophils have been targeted with successful results.
However, even in brain lesions, neutrophils also exert beneficial effects, because they are involved in triggering immunological removal of cell debris.
Furthermore, intact neutrophil function is essential for maintaining immunological defense against bacterial infections.
Several studies have demonstrated that stroke-derived neutrophils displayed impaired bacterial defense capacity.
Because infections are known to impair the clinical course of stroke, therapeutic interventions that target neutrophils should preserve or even restore their function outside the central nervous system (CNS).
This complex situation requires well-tailored therapeutic approaches that can effectively tackle immune cell invasion in the brain but avoid increasing poststroke infections.
American Psychological Association (APA)
Ruhnau, Johanna& Schulze, Juliane& Dressel, Alexander& Vogelgesang, Antje. 2017. Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181897
Modern Language Association (MLA)
Ruhnau, Johanna…[et al.]. Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181897
American Medical Association (AMA)
Ruhnau, Johanna& Schulze, Juliane& Dressel, Alexander& Vogelgesang, Antje. Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181897