The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy

المؤلفون المشاركون

Bruening, Janina
Weigel, Bettina
Gerold, Gisa

المصدر

Journal of Immunology Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-02-01

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الأحياء

الملخص EN

The human interferon (IFN) response is a key innate immune mechanism to fight virus infection.

IFNs are host-encoded secreted proteins, which induce IFN-stimulated genes (ISGs) with antiviral properties.

Among the three classes of IFNs, type III IFNs, also called IFN lambdas (IFNLs), are an essential component of the innate immune response to hepatitis C virus (HCV).

In particular, human polymorphisms in IFNL gene loci correlate with hepatitis C disease progression and with treatment response.

To date, the underlying mechanisms remain mostly elusive; however it seems clear that viral infection of the liver induces IFNL responses.

As IFNL receptors show a more restricted tissue expression than receptors for other classes of IFNs, IFNL treatment has reduced side effects compared to the classical type I IFN treatment.

In HCV therapy, however, IFNL will likely not play an important role as highly effective direct acting antivirals (DAA) exist.

Here, we will review our current knowledge on IFNL gene expression, protein properties, signaling, ISG induction, and its implications on HCV infection and treatment.

Finally, we will discuss the lessons learnt from the HCV and IFNL field for virus infections beyond hepatitis C.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Bruening, Janina& Weigel, Bettina& Gerold, Gisa. 2017. The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182063

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Bruening, Janina…[et al.]. The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1182063

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Bruening, Janina& Weigel, Bettina& Gerold, Gisa. The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182063

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1182063