The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy
Joint Authors
Bruening, Janina
Weigel, Bettina
Gerold, Gisa
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The human interferon (IFN) response is a key innate immune mechanism to fight virus infection.
IFNs are host-encoded secreted proteins, which induce IFN-stimulated genes (ISGs) with antiviral properties.
Among the three classes of IFNs, type III IFNs, also called IFN lambdas (IFNLs), are an essential component of the innate immune response to hepatitis C virus (HCV).
In particular, human polymorphisms in IFNL gene loci correlate with hepatitis C disease progression and with treatment response.
To date, the underlying mechanisms remain mostly elusive; however it seems clear that viral infection of the liver induces IFNL responses.
As IFNL receptors show a more restricted tissue expression than receptors for other classes of IFNs, IFNL treatment has reduced side effects compared to the classical type I IFN treatment.
In HCV therapy, however, IFNL will likely not play an important role as highly effective direct acting antivirals (DAA) exist.
Here, we will review our current knowledge on IFNL gene expression, protein properties, signaling, ISG induction, and its implications on HCV infection and treatment.
Finally, we will discuss the lessons learnt from the HCV and IFNL field for virus infections beyond hepatitis C.
American Psychological Association (APA)
Bruening, Janina& Weigel, Bettina& Gerold, Gisa. 2017. The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182063
Modern Language Association (MLA)
Bruening, Janina…[et al.]. The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1182063
American Medical Association (AMA)
Bruening, Janina& Weigel, Bettina& Gerold, Gisa. The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182063