Fabrication of Mn2+-Doped Hollow Mesoporous Aluminosilica Nanoparticles for Magnetic Resonance Imaging and Drug Delivery for Therapy of Colorectal Cancer

الملخص EN

A novel Mn2+-doped hollow Mn-HMAS aluminosilica (Mn-HMAS) nanoparticle for simultaneous T1-weighted magnetic resonance imaging and drug delivery was reported.

The magnetic resonance tests showed that the Mn-HMAS nanoparticles display an excellent T1-weighted magnetic resonance imaging effect with a high T1 relaxivity (r1) of 8.8 mM-1S-1.

The MTT assays showed that the Mn-HMAS-DOX nanoparticles possess a better tumour cell inhibition effect than DOX.

In addition, the Mn-HMAS nanoparticles also exhibit good stability and noncytotoxicity.

These results demonstrated that the Mn-HMAS nanoparticles can be applied for the loading and delivery of various drugs in medicine.