Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines
المؤلفون المشاركون
Kim, Seung Il
Kim, Gun-Hwa
Choi, Chi-Won
Park, Edmond Changkyun
Yun, Sung Ho
Lee, Sang-Yeop
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The secretion of extracellular membrane vesicles (EMVs) is a common phenomenon that occurs in archaea, bacteria, and mammalian cells.
The EMVs of bacteria play important roles in their virulence, biogenesis mechanisms, and host cell interactions.
Bacterial EMVs have recently become the focus of attention because of their potential as highly effective vaccines that cause few side effects.
Here, we isolated the EMVs of Streptococcus pneumoniae and examined their potential as new vaccine candidates.
Although the S.
pneumoniae bacteria were highly pathogenic in a mouse model, the EMVs purified from these bacteria showed low pathological activity both in cell culture and in mice.
When mice were injected intraperitoneally with S.
pneumoniae EMVs and then challenged, they were protected from both the homologous strain and another pathogenic serotype of S.
pneumoniae.
We also identified a number of proteins that may have immunogenic activity and may be responsible for the immune responses by the hosts.
These results suggest that S.
pneumoniae EMVs or their individual immunogenic antigens may be useful as new vaccine agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Chi-Won& Park, Edmond Changkyun& Yun, Sung Ho& Lee, Sang-Yeop& Kim, Seung Il& Kim, Gun-Hwa. 2017. Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1182097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Chi-Won…[et al.]. Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1182097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Chi-Won& Park, Edmond Changkyun& Yun, Sung Ho& Lee, Sang-Yeop& Kim, Seung Il& Kim, Gun-Hwa. Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1182097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر