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Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines
Joint Authors
Kim, Seung Il
Kim, Gun-Hwa
Choi, Chi-Won
Park, Edmond Changkyun
Yun, Sung Ho
Lee, Sang-Yeop
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The secretion of extracellular membrane vesicles (EMVs) is a common phenomenon that occurs in archaea, bacteria, and mammalian cells.
The EMVs of bacteria play important roles in their virulence, biogenesis mechanisms, and host cell interactions.
Bacterial EMVs have recently become the focus of attention because of their potential as highly effective vaccines that cause few side effects.
Here, we isolated the EMVs of Streptococcus pneumoniae and examined their potential as new vaccine candidates.
Although the S.
pneumoniae bacteria were highly pathogenic in a mouse model, the EMVs purified from these bacteria showed low pathological activity both in cell culture and in mice.
When mice were injected intraperitoneally with S.
pneumoniae EMVs and then challenged, they were protected from both the homologous strain and another pathogenic serotype of S.
pneumoniae.
We also identified a number of proteins that may have immunogenic activity and may be responsible for the immune responses by the hosts.
These results suggest that S.
pneumoniae EMVs or their individual immunogenic antigens may be useful as new vaccine agents.
American Psychological Association (APA)
Choi, Chi-Won& Park, Edmond Changkyun& Yun, Sung Ho& Lee, Sang-Yeop& Kim, Seung Il& Kim, Gun-Hwa. 2017. Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1182097
Modern Language Association (MLA)
Choi, Chi-Won…[et al.]. Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1182097
American Medical Association (AMA)
Choi, Chi-Won& Park, Edmond Changkyun& Yun, Sung Ho& Lee, Sang-Yeop& Kim, Seung Il& Kim, Gun-Hwa. Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1182097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182097