Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status
المؤلفون المشاركون
Gerhard, Markus
Ulm, Kurt
Formichella, Luca
Romberg, Laura
Meyer, Hannelore
Bolz, Christian
Geppert, Michael
Göttner, Gereon
Nölting, Christina
Schepp, Wolfgang
Schneider, Arne
Holster, Ingrid Lisanne
Kuipers, Ernst J.
Birkner, Bernd
Soutschek, Erwin
Wolf, Petra
Vieth, Michael
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Helicobacter pylori infection shows a worldwide prevalence of around 50%.
However, only a minority of infected individuals develop clinical symptoms or diseases.
The presence of H.
pylori virulence factors, such as CagA and VacA, has been associated with disease development, but assessment of virulence factor presence requires gastric biopsies.
Here, we evaluate the H.
pylori recomLine test for risk stratification of infected patients by comparing the test score and immune recognition of type I or type II strains defined by the virulence factors CagA, VacA, GroEL, UreA, HcpC, and gGT with patient’s disease status according to histology.
Moreover, the immune responses of eradicated individuals from two different populations were analysed.
Their immune response frequencies and intensities against all antigens except CagA declined below the detection limit.
CagA was particularly long lasting in both independent populations.
An isolated CagA band often represents past eradication with a likelihood of 88.7%.
In addition, a high recomLine score was significantly associated with high-grade gastritis, atrophy, intestinal metaplasia, and gastric cancer.
Thus, the recomLine is a sensitive and specific noninvasive test for detecting serum responses against H.
pylori in actively infected and eradicated individuals.
Moreover, it allows stratifying patients according to their disease state.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Formichella, Luca& Romberg, Laura& Meyer, Hannelore& Bolz, Christian& Vieth, Michael& Geppert, Michael…[et al.]. 2017. Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Formichella, Luca…[et al.]. Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1182137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Formichella, Luca& Romberg, Laura& Meyer, Hannelore& Bolz, Christian& Vieth, Michael& Geppert, Michael…[et al.]. Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر