Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status
Joint Authors
Gerhard, Markus
Ulm, Kurt
Formichella, Luca
Romberg, Laura
Meyer, Hannelore
Bolz, Christian
Geppert, Michael
Göttner, Gereon
Nölting, Christina
Schepp, Wolfgang
Schneider, Arne
Holster, Ingrid Lisanne
Kuipers, Ernst J.
Birkner, Bernd
Soutschek, Erwin
Wolf, Petra
Vieth, Michael
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Helicobacter pylori infection shows a worldwide prevalence of around 50%.
However, only a minority of infected individuals develop clinical symptoms or diseases.
The presence of H.
pylori virulence factors, such as CagA and VacA, has been associated with disease development, but assessment of virulence factor presence requires gastric biopsies.
Here, we evaluate the H.
pylori recomLine test for risk stratification of infected patients by comparing the test score and immune recognition of type I or type II strains defined by the virulence factors CagA, VacA, GroEL, UreA, HcpC, and gGT with patient’s disease status according to histology.
Moreover, the immune responses of eradicated individuals from two different populations were analysed.
Their immune response frequencies and intensities against all antigens except CagA declined below the detection limit.
CagA was particularly long lasting in both independent populations.
An isolated CagA band often represents past eradication with a likelihood of 88.7%.
In addition, a high recomLine score was significantly associated with high-grade gastritis, atrophy, intestinal metaplasia, and gastric cancer.
Thus, the recomLine is a sensitive and specific noninvasive test for detecting serum responses against H.
pylori in actively infected and eradicated individuals.
Moreover, it allows stratifying patients according to their disease state.
American Psychological Association (APA)
Formichella, Luca& Romberg, Laura& Meyer, Hannelore& Bolz, Christian& Vieth, Michael& Geppert, Michael…[et al.]. 2017. Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182137
Modern Language Association (MLA)
Formichella, Luca…[et al.]. Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1182137
American Medical Association (AMA)
Formichella, Luca& Romberg, Laura& Meyer, Hannelore& Bolz, Christian& Vieth, Michael& Geppert, Michael…[et al.]. Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182137