Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

المؤلفون المشاركون

Wang, Mengyue
Li, Xiaobo
Peng, Ying
Xu, Renjie

المصدر

Journal of Chemistry

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-03-13

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء

الملخص EN

Alantolactone and isoalantolactone are the major active ingredients of Inulae Radix.

Their metabolism in vivo and in vitro was investigated by UPLC-Q-TOF-MS for the first time.

As a result, nine metabolites in vivo including cysteine conjugates, oxidates, dehydrogenates, and hydrates were detected in rat bile after oral administration.

The metabolites produced in vitro by incubation with rat liver microsomes were found to be substantially identical to those detected in vivo.

However, no metabolites were detected in the samples of plasma, feces, and urine or in the incubates of gastric juice, intestinal juice, and intestinal bacteria.

These results reveal that the liver is the main metabolic organ for alantolactone and isoalantolactone, and the first pass effect of the liver appears to be the reason for the low oral bioavailability of the two lactones.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Mengyue& Xu, Renjie& Peng, Ying& Li, Xiaobo. 2018. Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1182169

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Mengyue…[et al.]. Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration. Journal of Chemistry No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1182169

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Mengyue& Xu, Renjie& Peng, Ying& Li, Xiaobo. Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1182169

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1182169