Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration
Joint Authors
Wang, Mengyue
Li, Xiaobo
Peng, Ying
Xu, Renjie
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alantolactone and isoalantolactone are the major active ingredients of Inulae Radix.
Their metabolism in vivo and in vitro was investigated by UPLC-Q-TOF-MS for the first time.
As a result, nine metabolites in vivo including cysteine conjugates, oxidates, dehydrogenates, and hydrates were detected in rat bile after oral administration.
The metabolites produced in vitro by incubation with rat liver microsomes were found to be substantially identical to those detected in vivo.
However, no metabolites were detected in the samples of plasma, feces, and urine or in the incubates of gastric juice, intestinal juice, and intestinal bacteria.
These results reveal that the liver is the main metabolic organ for alantolactone and isoalantolactone, and the first pass effect of the liver appears to be the reason for the low oral bioavailability of the two lactones.
American Psychological Association (APA)
Wang, Mengyue& Xu, Renjie& Peng, Ying& Li, Xiaobo. 2018. Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1182169
Modern Language Association (MLA)
Wang, Mengyue…[et al.]. Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration. Journal of Chemistry No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1182169
American Medical Association (AMA)
Wang, Mengyue& Xu, Renjie& Peng, Ying& Li, Xiaobo. Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1182169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182169