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Effect of Chitosan and Liposome Nanoparticles as Adjuvant Codelivery on the Immunoglobulin G Subclass Distribution in a Mouse Model
المؤلفون المشاركون
Haryono, Agus
Salsabila, Korrie
Restu, Witta Kartika
Harmami, Sri Budi
Safari, Dodi
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-05
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
We investigate the immunogenic properties of chitosan and liposome nanoparticles as adjuvant codelivery against a commercial pneumococcal conjugate vaccine (PCV) in an animal model.
Methods.
The chitosan and liposome nanoparticles were prepared by ionic gelation and dry methods, respectively.
The PCV immunization was performed intradermally in the presence of adjuvants and booster injections which were given without an adjuvant.
The Quil-A® was used as a control adjuvant.
The ELISA was performed to measure the antibodies against pneumococcal type 14 polysaccharide (Pn14PS).
Results.
The level of total antibodies against Pn14PS antigen was no different between the mouse groups with or without adjuvant codelivery.
Codelivery of the PCV with chitosan nanoparticles as well as the Quil-A adjuvant elicited IgG1, IgG2a, IgG2b, and IgG3 antibodies.
Meanwhile, codelivery of liposome nanoparticles elicited mainly IgG1 antibodies against the Pn14PS.
Conclusions.
The chitosan and liposome nanoparticles as adjuvant codelivery were successfully synthesized.
These nanoparticles have different shapes in particle formation, liposome nanoparticle with their unilamellar shape and chitosan nanoparticles in large shape due to the aggregation of small-size particles.
Codelivery of chitosan nanoparticles has more effect on the IgG subclass antibody production than that of liposome nanoparticles in a mouse model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haryono, Agus& Salsabila, Korrie& Restu, Witta Kartika& Harmami, Sri Budi& Safari, Dodi. 2017. Effect of Chitosan and Liposome Nanoparticles as Adjuvant Codelivery on the Immunoglobulin G Subclass Distribution in a Mouse Model. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1182218
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haryono, Agus…[et al.]. Effect of Chitosan and Liposome Nanoparticles as Adjuvant Codelivery on the Immunoglobulin G Subclass Distribution in a Mouse Model. Journal of Immunology Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1182218
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haryono, Agus& Salsabila, Korrie& Restu, Witta Kartika& Harmami, Sri Budi& Safari, Dodi. Effect of Chitosan and Liposome Nanoparticles as Adjuvant Codelivery on the Immunoglobulin G Subclass Distribution in a Mouse Model. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1182218
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182218
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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