Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation
المؤلفون المشاركون
Chen, Huaiyong
Wu, Qi
Wu, Junping
Li, Yu
Xu, Long
Wan, Zhen
Li, Li
Yu, Hongzhi
Li, Xue
Li, Kuan
Zhang, Qiuyang
Hou, Zhili
Sun, Xin
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Chronic inflammation is associated with an increased number of leukocytes in the spleen, which are then redirected to the site of inflammation.
However, it remains unknown how leukocyte recruitment is regulated.
Herein, chronic inflammation was induced by intraperitoneal injection of pristane into mice.
Leukocytes in the spleen or in the peritoneal cavity were quantified by flow cytometry.
We found that the loss of IL-6 decreased macrophage recruitment to the spleen and the peritoneal cavity during pristane-induced inflammation.
The loss of TNFα delayed the recruitment of neutrophils and macrophages to the spleen and inhibited the recruitment of neutrophils, macrophages, B cells, and T cells.
The recruitment of neutrophils and macrophages into the spleen or peritoneal cavity was largely inhibited in the absence of LTα.
The loss of TNFα receptor 1/2 resulted in reduced recruitment of neutrophils, macrophages, and dendritic cells into the spleen, but only neutrophil recruitment was inhibited in the peritoneal cavity.
Similarly, a lack of B cells significantly impeded the recruitment of neutrophils, macrophages, and dendritic cells to the spleen.
However, only macrophage recruitment was inhibited in the absence of T cells in the spleen.
These data provide insight into the development of chronic inflammation induced by noninfectious substances.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yu& Wu, Junping& Xu, Long& Wu, Qi& Wan, Zhen& Li, Li…[et al.]. 2017. Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yu…[et al.]. Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1182289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yu& Wu, Junping& Xu, Long& Wu, Qi& Wan, Zhen& Li, Li…[et al.]. Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر