Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation
Joint Authors
Chen, Huaiyong
Wu, Qi
Wu, Junping
Li, Yu
Xu, Long
Wan, Zhen
Li, Li
Yu, Hongzhi
Li, Xue
Li, Kuan
Zhang, Qiuyang
Hou, Zhili
Sun, Xin
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chronic inflammation is associated with an increased number of leukocytes in the spleen, which are then redirected to the site of inflammation.
However, it remains unknown how leukocyte recruitment is regulated.
Herein, chronic inflammation was induced by intraperitoneal injection of pristane into mice.
Leukocytes in the spleen or in the peritoneal cavity were quantified by flow cytometry.
We found that the loss of IL-6 decreased macrophage recruitment to the spleen and the peritoneal cavity during pristane-induced inflammation.
The loss of TNFα delayed the recruitment of neutrophils and macrophages to the spleen and inhibited the recruitment of neutrophils, macrophages, B cells, and T cells.
The recruitment of neutrophils and macrophages into the spleen or peritoneal cavity was largely inhibited in the absence of LTα.
The loss of TNFα receptor 1/2 resulted in reduced recruitment of neutrophils, macrophages, and dendritic cells into the spleen, but only neutrophil recruitment was inhibited in the peritoneal cavity.
Similarly, a lack of B cells significantly impeded the recruitment of neutrophils, macrophages, and dendritic cells to the spleen.
However, only macrophage recruitment was inhibited in the absence of T cells in the spleen.
These data provide insight into the development of chronic inflammation induced by noninfectious substances.
American Psychological Association (APA)
Li, Yu& Wu, Junping& Xu, Long& Wu, Qi& Wan, Zhen& Li, Li…[et al.]. 2017. Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182289
Modern Language Association (MLA)
Li, Yu…[et al.]. Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1182289
American Medical Association (AMA)
Li, Yu& Wu, Junping& Xu, Long& Wu, Qi& Wan, Zhen& Li, Li…[et al.]. Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1182289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182289