FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin
المؤلفون المشاركون
Salgado, Hérida Regina Nunes
Fanelli, Stefany
Zimmermann, Alexander
Totóli, Eliane Gandolpho
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds.
Its bactericidal action causes a destruction of the cell wall of bacteria.
It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME).
In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules.
Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region.
The analyses were performed in the spectral range of 1815–1736 cm−1, and the samples were analyzed as potassium bromide pellets.
The method was validated according to the ICH guidelines and Brazilian legislation.
Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5–1.5 mg/pellet.
Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules.
In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fanelli, Stefany& Zimmermann, Alexander& Totóli, Eliane Gandolpho& Salgado, Hérida Regina Nunes. 2018. FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1182294
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fanelli, Stefany…[et al.]. FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin. Journal of Chemistry No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1182294
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fanelli, Stefany& Zimmermann, Alexander& Totóli, Eliane Gandolpho& Salgado, Hérida Regina Nunes. FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1182294
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182294
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر