FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin
Joint Authors
Salgado, Hérida Regina Nunes
Fanelli, Stefany
Zimmermann, Alexander
Totóli, Eliane Gandolpho
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds.
Its bactericidal action causes a destruction of the cell wall of bacteria.
It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME).
In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules.
Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region.
The analyses were performed in the spectral range of 1815–1736 cm−1, and the samples were analyzed as potassium bromide pellets.
The method was validated according to the ICH guidelines and Brazilian legislation.
Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5–1.5 mg/pellet.
Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules.
In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug.
American Psychological Association (APA)
Fanelli, Stefany& Zimmermann, Alexander& Totóli, Eliane Gandolpho& Salgado, Hérida Regina Nunes. 2018. FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1182294
Modern Language Association (MLA)
Fanelli, Stefany…[et al.]. FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin. Journal of Chemistry No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1182294
American Medical Association (AMA)
Fanelli, Stefany& Zimmermann, Alexander& Totóli, Eliane Gandolpho& Salgado, Hérida Regina Nunes. FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1182294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182294