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Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis
المؤلفون المشاركون
Srivastava, Rajeshwar N.
Mishra, Abhishek
Awasthi, Sachin
Mishra, Priya
Parmar, Devendra
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Introduction.
Genetic factors including the level of expression of the fingerprint of genes involved in the development of bones and cartilage such as GDF-5 or ESR-α or CALM-1 are known to be strong determinants of the osteoarthritis (OA) in Caucasian and Oriental populations.
Because of high prevalence of OA in Indian population and availability of limited genetic data, we determined whether similar genetic factors are involved in Indians as well.
Methods.
A case control study was carried out involving 500 patients of knee OA and equal number of healthy controls.
Genotyping analyses in whole blood, mRNA, and protein expressions in peripheral blood lymphocytes (PBLs) were performed using established protocols.
Results.
Our results showed a significantly decreased level of mRNA and protein expressions for GDF-5, ESR-α, and CALM-1 genes in PBLs of OA cases when compared to healthy controls.
The frequency of variant genotypes of these genes was also increased significantly in cases of OA compared to controls.
Conclusion.
Our results demonstrated that the decrease in expression of GDF-5, ESR-α, and CALM-1 in PBLs and association of polymorphism in these genes may be important in predicting the severity and thereby the progression of OA in Indian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mishra, Abhishek& Srivastava, Rajeshwar N.& Awasthi, Sachin& Parmar, Devendra& Mishra, Priya. 2017. Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis. Journal of Nucleic Acids،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182448
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mishra, Abhishek…[et al.]. Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis. Journal of Nucleic Acids No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1182448
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mishra, Abhishek& Srivastava, Rajeshwar N.& Awasthi, Sachin& Parmar, Devendra& Mishra, Priya. Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis. Journal of Nucleic Acids. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182448
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182448
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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