Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis
Joint Authors
Srivastava, Rajeshwar N.
Mishra, Abhishek
Awasthi, Sachin
Mishra, Priya
Parmar, Devendra
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Genetic factors including the level of expression of the fingerprint of genes involved in the development of bones and cartilage such as GDF-5 or ESR-α or CALM-1 are known to be strong determinants of the osteoarthritis (OA) in Caucasian and Oriental populations.
Because of high prevalence of OA in Indian population and availability of limited genetic data, we determined whether similar genetic factors are involved in Indians as well.
Methods.
A case control study was carried out involving 500 patients of knee OA and equal number of healthy controls.
Genotyping analyses in whole blood, mRNA, and protein expressions in peripheral blood lymphocytes (PBLs) were performed using established protocols.
Results.
Our results showed a significantly decreased level of mRNA and protein expressions for GDF-5, ESR-α, and CALM-1 genes in PBLs of OA cases when compared to healthy controls.
The frequency of variant genotypes of these genes was also increased significantly in cases of OA compared to controls.
Conclusion.
Our results demonstrated that the decrease in expression of GDF-5, ESR-α, and CALM-1 in PBLs and association of polymorphism in these genes may be important in predicting the severity and thereby the progression of OA in Indian population.
American Psychological Association (APA)
Mishra, Abhishek& Srivastava, Rajeshwar N.& Awasthi, Sachin& Parmar, Devendra& Mishra, Priya. 2017. Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis. Journal of Nucleic Acids،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182448
Modern Language Association (MLA)
Mishra, Abhishek…[et al.]. Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis. Journal of Nucleic Acids No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1182448
American Medical Association (AMA)
Mishra, Abhishek& Srivastava, Rajeshwar N.& Awasthi, Sachin& Parmar, Devendra& Mishra, Priya. Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis. Journal of Nucleic Acids. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182448