Physical Absorption of Folic Acid and Chitosan on Dihydroartemisinin-Loaded Poly-Lactic-Co-Glycolic Acid Nanoparticles via Electrostatic Interaction for Their Enhanced Uptake and Anticancer Effect
المؤلفون المشاركون
Nguyen, Chien Ngoc
Tran, Bao Ngoc
Thi, Hoa Nguyen
Huu, Phong Pham
Thi, Huong Nguyen
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-13
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
In this study, dihydroartemisinin (DAR), an anticancer agent with low toxicity, was loaded into poly-lactic-co-glycolic acid (PLGA) nanoparticles.
The obtained PLGA cores were then coated with chitosan (CS) and/or folic acid (FA) by electrostatic interactions to enhance their anticancer and cellular uptake properties.
DAR-loaded PLGA nanoparticles were prepared by the solvent evaporation method.
CS and FA solutions at different ratios were dispersed concurrently into the PLGA suspension to facilitate electrostatic interactions and form nanosuspensions.
The physiochemical properties of nanoparticles such as average particle size (Z), polydispersity index (PDI), zeta potential (ZP), TEM image, X-ray diffraction, and encapsulation efficiency were determined.
We then determined the role of FA and CS coating on the nanoparticle surface in cytotoxicity, cellular uptake, and apoptosis.
We show that the resultant nanoparticles were spherical and uniform, with a coating layer containing FA and CS covering PLGA cores with a Z of 223.5±4.28 nm, PDI of 0.209±0.03, and ZP of 15.75±1.3 mV.
Both FA and CS improved the cytotoxicity of nanoparticles compared to free DAR and PLGA nanoparticles in HL-60 and KB cancer cell lines.
Further, FA enhanced the cellular uptake of nanoparticles to a greater extent than CS.
However, CS contributed more to apoptosis induction than FA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nguyen, Chien Ngoc& Tran, Bao Ngoc& Thi, Hoa Nguyen& Huu, Phong Pham& Thi, Huong Nguyen. 2019. Physical Absorption of Folic Acid and Chitosan on Dihydroartemisinin-Loaded Poly-Lactic-Co-Glycolic Acid Nanoparticles via Electrostatic Interaction for Their Enhanced Uptake and Anticancer Effect. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1182830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nguyen, Chien Ngoc…[et al.]. Physical Absorption of Folic Acid and Chitosan on Dihydroartemisinin-Loaded Poly-Lactic-Co-Glycolic Acid Nanoparticles via Electrostatic Interaction for Their Enhanced Uptake and Anticancer Effect. Journal of Nanomaterials No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1182830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nguyen, Chien Ngoc& Tran, Bao Ngoc& Thi, Hoa Nguyen& Huu, Phong Pham& Thi, Huong Nguyen. Physical Absorption of Folic Acid and Chitosan on Dihydroartemisinin-Loaded Poly-Lactic-Co-Glycolic Acid Nanoparticles via Electrostatic Interaction for Their Enhanced Uptake and Anticancer Effect. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1182830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر