Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats
المؤلفون المشاركون
Ishida, Susumu
Shinohara, Masami
Kikuchi, Kasumi
Murata, Miyuki
Kase, Satoru
Tagawa, Yoshiaki
Kageyama, Yasushi
Noda, Kousuke
Sasase, Tomohiko
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Spontaneously Diabetic Torii (SDT) fatty rat is a novel animal model of type 2 diabetes with obesity.
SDT fatty rats develop hyperglycemia, dyslipidemia, and other diabetic complications including ocular disorders; however, diabetic cataract formation in SDT fatty rats has not been fully investigated.
The aim of the current study was to investigate the characteristics of cataract in the SDT fatty rats.
The mean body weight of SDT fatty rats is larger than that of age-matched Sprague-Dawley (SD) rats and control animals until 8 weeks of age, and thereafter the growing speed decreased until the end of observation at 16 weeks of age.
Blood glucose levels in SDT fatty rats were significantly higher than those in SD rats throughout the observational period.
Slit-lamp examination revealed that no rats showed cataract formation at 5 weeks of age; however, SDT fatty rats gradually developed cortical cataract and posterior subcapsular cataract, both of which are the common types of cataract in patients with type 2 diabetes.
The levels of glucose, sorbitol, and fructose were higher in the lens tissues of SDT fatty rats in comparison with that of SD rats.
Furthermore, the level of 4-hydroxynonenal (4-HNE) was higher in the lens of SDT fatty rats than in that of SD rats.
By contrast, total glutathione (GSH) concentration was lower in the lens of SDT fatty rats than in that of SD rats.
The present study demonstrated that the cataractogenesis in SDT fatty rats resembled human diabetic cataract formation, indicating that SDT fatty rats serve as a potential animal model in researches on human cataract associated with type 2 diabetes and obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kikuchi, Kasumi& Murata, Miyuki& Noda, Kousuke& Kase, Satoru& Tagawa, Yoshiaki& Kageyama, Yasushi…[et al.]. 2020. Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183002
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kikuchi, Kasumi…[et al.]. Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats. Journal of Diabetes Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1183002
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kikuchi, Kasumi& Murata, Miyuki& Noda, Kousuke& Kase, Satoru& Tagawa, Yoshiaki& Kageyama, Yasushi…[et al.]. Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183002
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183002
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر