Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats

Joint Authors

Ishida, Susumu
Shinohara, Masami
Kikuchi, Kasumi
Murata, Miyuki
Kase, Satoru
Tagawa, Yoshiaki
Kageyama, Yasushi
Noda, Kousuke
Sasase, Tomohiko

Source

Journal of Diabetes Research

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-08-03

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases
Medicine

Abstract EN

Spontaneously Diabetic Torii (SDT) fatty rat is a novel animal model of type 2 diabetes with obesity.

SDT fatty rats develop hyperglycemia, dyslipidemia, and other diabetic complications including ocular disorders; however, diabetic cataract formation in SDT fatty rats has not been fully investigated.

The aim of the current study was to investigate the characteristics of cataract in the SDT fatty rats.

The mean body weight of SDT fatty rats is larger than that of age-matched Sprague-Dawley (SD) rats and control animals until 8 weeks of age, and thereafter the growing speed decreased until the end of observation at 16 weeks of age.

Blood glucose levels in SDT fatty rats were significantly higher than those in SD rats throughout the observational period.

Slit-lamp examination revealed that no rats showed cataract formation at 5 weeks of age; however, SDT fatty rats gradually developed cortical cataract and posterior subcapsular cataract, both of which are the common types of cataract in patients with type 2 diabetes.

The levels of glucose, sorbitol, and fructose were higher in the lens tissues of SDT fatty rats in comparison with that of SD rats.

Furthermore, the level of 4-hydroxynonenal (4-HNE) was higher in the lens of SDT fatty rats than in that of SD rats.

By contrast, total glutathione (GSH) concentration was lower in the lens of SDT fatty rats than in that of SD rats.

The present study demonstrated that the cataractogenesis in SDT fatty rats resembled human diabetic cataract formation, indicating that SDT fatty rats serve as a potential animal model in researches on human cataract associated with type 2 diabetes and obesity.

American Psychological Association (APA)

Kikuchi, Kasumi& Murata, Miyuki& Noda, Kousuke& Kase, Satoru& Tagawa, Yoshiaki& Kageyama, Yasushi…[et al.]. 2020. Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183002

Modern Language Association (MLA)

Kikuchi, Kasumi…[et al.]. Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats. Journal of Diabetes Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1183002

American Medical Association (AMA)

Kikuchi, Kasumi& Murata, Miyuki& Noda, Kousuke& Kase, Satoru& Tagawa, Yoshiaki& Kageyama, Yasushi…[et al.]. Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183002

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1183002