An Injectable Composite Gelatin Hydrogel with pH Response Properties

المؤلفون المشاركون

Chen, Baoguo
Zhang, Guojun

المصدر

Journal of Nanomaterials

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-01-11

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء
هندسة مدنية

الملخص EN

On account of minimally invasive procedure and of filling irregular defects of tissues, injectable hydrogels are increasingly attractive in biomedical fields.

However, traditional hydrogel formed by simple physical interaction or in situ crosslinking had inevitably some drawbacks such as low mechanical strength and lack of multifunctional properties.

Though many investigations had successfully modified traditional injectable hydrogel to obtain both mechanical and functional properties, an acetalated β-cyclodextrin (Ac-β-CD) nanoparticle composite injectable hydrogel designed in the research was another effective and efficient choice to solve the drawbacks.

First of all, gelatin derivative (G-AA) and Ac-β-CD were synthesized to prepare hydrogel and nanoparticle, respectively.

In order to ensure good compatibility between nanoparticle and macromonomer and provide crosslink points between nanoparticle and macromonomer, G-AA was simultaneously functionalized onto the surface of Ac-β-CD nanoparticle during the fabrication of Ac-β-CD nanoparticle using one-step method.

Finally, injectable composite hydrogel was obtained by photoinitiated polymerization in situ.

Hydrogel properties like gelation time and swelling ratio were investigated.

The viscoelastic behavior of hydrogels confirmed that typical characteristics of crosslinked elastomer for all hydrogel and nanoparticle in hydrogel could improve the mechanical property of hydrogel.

Moreover, the transparency with time had verified obvious acid-response properties of hydrogels.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chen, Baoguo& Zhang, Guojun. 2017. An Injectable Composite Gelatin Hydrogel with pH Response Properties. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1183151

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chen, Baoguo& Zhang, Guojun. An Injectable Composite Gelatin Hydrogel with pH Response Properties. Journal of Nanomaterials No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1183151

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chen, Baoguo& Zhang, Guojun. An Injectable Composite Gelatin Hydrogel with pH Response Properties. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1183151

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1183151