![](/images/graphics-bg.png)
An Injectable Composite Gelatin Hydrogel with pH Response Properties
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
On account of minimally invasive procedure and of filling irregular defects of tissues, injectable hydrogels are increasingly attractive in biomedical fields.
However, traditional hydrogel formed by simple physical interaction or in situ crosslinking had inevitably some drawbacks such as low mechanical strength and lack of multifunctional properties.
Though many investigations had successfully modified traditional injectable hydrogel to obtain both mechanical and functional properties, an acetalated β-cyclodextrin (Ac-β-CD) nanoparticle composite injectable hydrogel designed in the research was another effective and efficient choice to solve the drawbacks.
First of all, gelatin derivative (G-AA) and Ac-β-CD were synthesized to prepare hydrogel and nanoparticle, respectively.
In order to ensure good compatibility between nanoparticle and macromonomer and provide crosslink points between nanoparticle and macromonomer, G-AA was simultaneously functionalized onto the surface of Ac-β-CD nanoparticle during the fabrication of Ac-β-CD nanoparticle using one-step method.
Finally, injectable composite hydrogel was obtained by photoinitiated polymerization in situ.
Hydrogel properties like gelation time and swelling ratio were investigated.
The viscoelastic behavior of hydrogels confirmed that typical characteristics of crosslinked elastomer for all hydrogel and nanoparticle in hydrogel could improve the mechanical property of hydrogel.
Moreover, the transparency with time had verified obvious acid-response properties of hydrogels.
American Psychological Association (APA)
Chen, Baoguo& Zhang, Guojun. 2017. An Injectable Composite Gelatin Hydrogel with pH Response Properties. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1183151
Modern Language Association (MLA)
Chen, Baoguo& Zhang, Guojun. An Injectable Composite Gelatin Hydrogel with pH Response Properties. Journal of Nanomaterials No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1183151
American Medical Association (AMA)
Chen, Baoguo& Zhang, Guojun. An Injectable Composite Gelatin Hydrogel with pH Response Properties. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1183151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183151