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Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine
المؤلفون المشاركون
Cuevas-Yañez, Erick
Ocampo-García, Blanca
González-Romero, Carlos
Ancira-Cortez, Alejandra
Morales-Avila, Enrique
Medina, Luis A.
López-Téllez, Gustavo
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cancer is one of the diseases with most deaths worldwide, around 8.2 million annually.
For this reason, several treatments and diagnostic tools have been investigated and developed over the past decades.
Among them, a dual-image system has been developed to achieve and enhance the detection of cancer, which has not been done with systems currently available.
The present study describes the preparation of a dual-image targeting system composed of magnetic iron oxide nanoparticles functionalized with folic acid and rhodamine; nanoparticles synthesis was achieved by a coprecipitation method; the functionalization was carried out by a carbodiimide with folic acid and/or the rhodamine isothiocyanate; conjugates were characterized by spectrometric techniques; toxicity was measured by cell proliferation assay on HeLa cells using progressive concentrations of functionalized nanoparticles.
Cellular uptake assay was carried out by competitive assay on HeLa cells.
Iron oxide magnetite nanoparticles, modified with folic acid and rhodamine, were successfully synthetized with a particle size lower than 20 nm (TEM), EDS, HRTEM, and XDR showed highly crystalline Fe3O4 nanoparticles.
Folic acid and rhodamine were conjugated with high efficiency.
A significant selectivity and uptake, facilitated by surface modification of iron oxide nanoparticles with folic acid, were demonstrated.
The multifunctional system showed suitable physicochemical and biological properties for cell targeting through folate receptors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ancira-Cortez, Alejandra& Morales-Avila, Enrique& Ocampo-García, Blanca& González-Romero, Carlos& Medina, Luis A.& López-Téllez, Gustavo…[et al.]. 2017. Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1183169
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ancira-Cortez, Alejandra…[et al.]. Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine. Journal of Nanomaterials No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1183169
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ancira-Cortez, Alejandra& Morales-Avila, Enrique& Ocampo-García, Blanca& González-Romero, Carlos& Medina, Luis A.& López-Téllez, Gustavo…[et al.]. Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1183169
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183169
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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