Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine
Joint Authors
Cuevas-Yañez, Erick
Ocampo-García, Blanca
González-Romero, Carlos
Ancira-Cortez, Alejandra
Morales-Avila, Enrique
Medina, Luis A.
López-Téllez, Gustavo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cancer is one of the diseases with most deaths worldwide, around 8.2 million annually.
For this reason, several treatments and diagnostic tools have been investigated and developed over the past decades.
Among them, a dual-image system has been developed to achieve and enhance the detection of cancer, which has not been done with systems currently available.
The present study describes the preparation of a dual-image targeting system composed of magnetic iron oxide nanoparticles functionalized with folic acid and rhodamine; nanoparticles synthesis was achieved by a coprecipitation method; the functionalization was carried out by a carbodiimide with folic acid and/or the rhodamine isothiocyanate; conjugates were characterized by spectrometric techniques; toxicity was measured by cell proliferation assay on HeLa cells using progressive concentrations of functionalized nanoparticles.
Cellular uptake assay was carried out by competitive assay on HeLa cells.
Iron oxide magnetite nanoparticles, modified with folic acid and rhodamine, were successfully synthetized with a particle size lower than 20 nm (TEM), EDS, HRTEM, and XDR showed highly crystalline Fe3O4 nanoparticles.
Folic acid and rhodamine were conjugated with high efficiency.
A significant selectivity and uptake, facilitated by surface modification of iron oxide nanoparticles with folic acid, were demonstrated.
The multifunctional system showed suitable physicochemical and biological properties for cell targeting through folate receptors.
American Psychological Association (APA)
Ancira-Cortez, Alejandra& Morales-Avila, Enrique& Ocampo-García, Blanca& González-Romero, Carlos& Medina, Luis A.& López-Téllez, Gustavo…[et al.]. 2017. Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1183169
Modern Language Association (MLA)
Ancira-Cortez, Alejandra…[et al.]. Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine. Journal of Nanomaterials No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1183169
American Medical Association (AMA)
Ancira-Cortez, Alejandra& Morales-Avila, Enrique& Ocampo-García, Blanca& González-Romero, Carlos& Medina, Luis A.& López-Téllez, Gustavo…[et al.]. Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1183169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183169