Vitamin D Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Suppressing Endoplasmic Reticulum Stress
المؤلفون المشاركون
Das, Sushant Kumar
Yuan, Yi Feng
Li, Mao Quan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
This study is designed to investigate whether vitamin D promotes diabetic wound healing and explore the potential mechanism which may be involved in the healing process.
Material and Methods.
Human umbilical vein endothelial cells (HUVECs) were treated with 200 μg/ml of advanced glycation end product-modified human serum albumin (AGE-HSA) and 250 mg/dl of glucose with vitamin D.
Cell viability was analyzed using the CCK-8 assay, and the apoptosis rate was measured using flow cytometry.
Endogenous markers of ER stress were quantified using Western blot and a real-time polymerase chain reaction.
Diabetic mice were treated with vitamin D (100 ng/kg per day) for 14 days.
The ulcer area and ulcerative histology were detected dynamically.
Results.
Vitamin D administration not only decreased the apoptosis rate but also increased cell viability.
Furthermore, the expression of endogenous markers of ER stress was downregulated as a result of vitamin D treatment.
Vitamin D supplementation significantly accelerated wound healing of diabetic mice and improved the healing quality.
Further studies showed that reduced ER stress was associated with the positive outcome.
Conclusion.
These results suggest that vitamin D may ameliorate impaired wound healing in diabetic mice by suppressing ER stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Yi Feng& Das, Sushant Kumar& Li, Mao Quan. 2018. Vitamin D Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Suppressing Endoplasmic Reticulum Stress. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183303
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Yi Feng…[et al.]. Vitamin D Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Suppressing Endoplasmic Reticulum Stress. Journal of Diabetes Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1183303
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Yi Feng& Das, Sushant Kumar& Li, Mao Quan. Vitamin D Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Suppressing Endoplasmic Reticulum Stress. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183303
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183303
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر