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In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes
المؤلفون المشاركون
Ali, Murtaza Najabat
Riaz, Zainab
Qureshi, Zunaira
Mohsin, Muhammad
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background/Aim.
Type 2 diabetes is the most common form of diabetes mellitus.
The aim of this study was to develop and standardize the polyhedral formulation (granule) and check its efficacy with regard to type 2 diabetes.
Methods.
The alcoholic extract of each plant (H.
antidysentrica, Prunus dulcis and Cicer arietinum) and oleic acid was mixed and then formulated by wet granulation method.
FTIR was done to investigate the presence of active compounds.
Physicochemical properties of granules were evaluated and antidiabetic potential was substantiated through inhibition of carbohydrate digestive enzyme (α-amylase and α-glucosidase), glucose uptake activity in yeast cells, and antioxidant activity.
Results.
IR spectra indicated the presence of active compounds by showing the characteristic peaks of phenols and amines.
The FTIR results also showed no interaction between drug and excipients.
The prepared granules exhibited excellent flow properties according to USP 30.
The dissolution profile of active pharmaceutical ingredient (API) from granules showed 72–80% release in 2 hrs.
Granules exhibited better inhibition of α-amylase and α-glucosidase as in comparison with the standard drug and found to be dose-dependent.
The enhanced uptake of glucose was observed with a decrease in drug concentration.
Moreover, the DPPH scavenging activity was high (98%) at 1 mg/ml.
Conclusion.
The stabilized formulation (granules) was formed and the presence of active compounds is responsible for better antidiabetic activity by inhibiting carbohydrate-digesting enzymes.
Hence, it could lower the postprandial hyperglycemia and has the potential to be used for the treatment of type II diabetes after determining the dose regime.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Riaz, Zainab& Ali, Murtaza Najabat& Qureshi, Zunaira& Mohsin, Muhammad. 2020. In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183368
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Riaz, Zainab…[et al.]. In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1183368
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Riaz, Zainab& Ali, Murtaza Najabat& Qureshi, Zunaira& Mohsin, Muhammad. In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183368
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183368
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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