In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes
Joint Authors
Ali, Murtaza Najabat
Riaz, Zainab
Qureshi, Zunaira
Mohsin, Muhammad
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background/Aim.
Type 2 diabetes is the most common form of diabetes mellitus.
The aim of this study was to develop and standardize the polyhedral formulation (granule) and check its efficacy with regard to type 2 diabetes.
Methods.
The alcoholic extract of each plant (H.
antidysentrica, Prunus dulcis and Cicer arietinum) and oleic acid was mixed and then formulated by wet granulation method.
FTIR was done to investigate the presence of active compounds.
Physicochemical properties of granules were evaluated and antidiabetic potential was substantiated through inhibition of carbohydrate digestive enzyme (α-amylase and α-glucosidase), glucose uptake activity in yeast cells, and antioxidant activity.
Results.
IR spectra indicated the presence of active compounds by showing the characteristic peaks of phenols and amines.
The FTIR results also showed no interaction between drug and excipients.
The prepared granules exhibited excellent flow properties according to USP 30.
The dissolution profile of active pharmaceutical ingredient (API) from granules showed 72–80% release in 2 hrs.
Granules exhibited better inhibition of α-amylase and α-glucosidase as in comparison with the standard drug and found to be dose-dependent.
The enhanced uptake of glucose was observed with a decrease in drug concentration.
Moreover, the DPPH scavenging activity was high (98%) at 1 mg/ml.
Conclusion.
The stabilized formulation (granules) was formed and the presence of active compounds is responsible for better antidiabetic activity by inhibiting carbohydrate-digesting enzymes.
Hence, it could lower the postprandial hyperglycemia and has the potential to be used for the treatment of type II diabetes after determining the dose regime.
American Psychological Association (APA)
Riaz, Zainab& Ali, Murtaza Najabat& Qureshi, Zunaira& Mohsin, Muhammad. 2020. In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183368
Modern Language Association (MLA)
Riaz, Zainab…[et al.]. In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1183368
American Medical Association (AMA)
Riaz, Zainab& Ali, Murtaza Najabat& Qureshi, Zunaira& Mohsin, Muhammad. In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183368