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Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-FedLow-Dose Streptozotocin-Treated Sprague Dawley Rats
المؤلفون المشاركون
Yorek, Mark A.
Shevalye, Hanna
Obrosov, Alexander
Davidson, Eric P.
Coppey, Lawrence J.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In this study, we wanted to extend our investigation of the efficacy of fish oil with or without salsalate on vascular and neural complications using a type 2 diabetic rat model.
Four weeks after the onset of hyperglycemia, diabetic rats were treated via the diet with 3 different amounts of menhaden oil with or without salsalate for 12 weeks.
Afterwards, vascular reactivity of epineurial arterioles and neuropathy-related endpoints were examined.
The addition of salsalate to high-fat diets enriched with 10% or 25% kcal of menhaden oil protected vascular reactivity to acetylcholine and calcium gene-related peptide, motor and sensory nerve conduction velocity, thermal nociception, intraepidermal nerve fiber density, and cornea sensitivity to a greater extent than 10% or 25% menhaden oil alone.
Vascular and neural function was maximally protected with diet containing 45% kcal as menhaden oil, and adding salsalate did not provide any additional benefit.
Salsalate alone in the high-fat diet of diabetic rats provided minimal protection/improvement of vascular and neural dysfunction.
These studies imply that dietary salsalate in combination with lower amounts of menhaden oil can provide greater benefit toward diabetes-induced vascular and neural impairment than menhaden oil alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Davidson, Eric P.& Coppey, Lawrence J.& Shevalye, Hanna& Obrosov, Alexander& Yorek, Mark A.. 2018. Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-FedLow-Dose Streptozotocin-Treated Sprague Dawley Rats. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Davidson, Eric P.…[et al.]. Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-FedLow-Dose Streptozotocin-Treated Sprague Dawley Rats. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Davidson, Eric P.& Coppey, Lawrence J.& Shevalye, Hanna& Obrosov, Alexander& Yorek, Mark A.. Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-FedLow-Dose Streptozotocin-Treated Sprague Dawley Rats. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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