Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-FedLow-Dose Streptozotocin-Treated Sprague Dawley Rats
Joint Authors
Yorek, Mark A.
Shevalye, Hanna
Obrosov, Alexander
Davidson, Eric P.
Coppey, Lawrence J.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this study, we wanted to extend our investigation of the efficacy of fish oil with or without salsalate on vascular and neural complications using a type 2 diabetic rat model.
Four weeks after the onset of hyperglycemia, diabetic rats were treated via the diet with 3 different amounts of menhaden oil with or without salsalate for 12 weeks.
Afterwards, vascular reactivity of epineurial arterioles and neuropathy-related endpoints were examined.
The addition of salsalate to high-fat diets enriched with 10% or 25% kcal of menhaden oil protected vascular reactivity to acetylcholine and calcium gene-related peptide, motor and sensory nerve conduction velocity, thermal nociception, intraepidermal nerve fiber density, and cornea sensitivity to a greater extent than 10% or 25% menhaden oil alone.
Vascular and neural function was maximally protected with diet containing 45% kcal as menhaden oil, and adding salsalate did not provide any additional benefit.
Salsalate alone in the high-fat diet of diabetic rats provided minimal protection/improvement of vascular and neural dysfunction.
These studies imply that dietary salsalate in combination with lower amounts of menhaden oil can provide greater benefit toward diabetes-induced vascular and neural impairment than menhaden oil alone.
American Psychological Association (APA)
Davidson, Eric P.& Coppey, Lawrence J.& Shevalye, Hanna& Obrosov, Alexander& Yorek, Mark A.. 2018. Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-FedLow-Dose Streptozotocin-Treated Sprague Dawley Rats. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183396
Modern Language Association (MLA)
Davidson, Eric P.…[et al.]. Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-FedLow-Dose Streptozotocin-Treated Sprague Dawley Rats. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183396
American Medical Association (AMA)
Davidson, Eric P.& Coppey, Lawrence J.& Shevalye, Hanna& Obrosov, Alexander& Yorek, Mark A.. Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-FedLow-Dose Streptozotocin-Treated Sprague Dawley Rats. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183396