![](/images/graphics-bg.png)
Ultrasonographic Characterization of the dbdb Mouse: An Animal Model of Metabolic Abnormalities
المؤلفون المشاركون
Kusmic, Claudia
Faita, Francesco
Di Lascio, Nicole
Rossi, Chiara
Solini, Anna
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The availability of an animal model able to reliably mirror organ damage occurring in metabolic diseases is an urgent need.
These models, mostly rodents, have not been fully characterized in terms of cardiovascular, renal, and hepatic ultrasound parameters, and only sparse values can be found in literature.
Aim of this paper is to provide a detailed, noninvasive description of the heart, vessels, liver, and kidneys of the db/db mouse by ultrasound imaging.
Sixteen wild type and thirty-four db/db male mice (11-week-old) were studied.
State-of-the-art ultrasound technology was used to acquire images of cardiovascular, renal, and hepatic districts.
A set of parameters describing function of the selected organs was evaluated.
db/db mice are characterized by systolic and diastolic dysfunction, confirmed by strain analysis.
Abdominal aortic and carotid stiffness do not seem to be increased in diabetic rodents; furthermore, they are characterized by a smaller mean diameter for both vessels.
Renal microcirculation is significantly compromised, while liver steatosis is only slightly higher in db/db mice than in controls.
We offer here for the first time an in vivo detailed ultrasonographic characterization of the db/db mouse, providing a useful tool for a thoughtful choice of the right rodent model for any experimental design.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Faita, Francesco& Di Lascio, Nicole& Rossi, Chiara& Kusmic, Claudia& Solini, Anna. 2018. Ultrasonographic Characterization of the dbdb Mouse: An Animal Model of Metabolic Abnormalities. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183544
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Faita, Francesco…[et al.]. Ultrasonographic Characterization of the dbdb Mouse: An Animal Model of Metabolic Abnormalities. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183544
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Faita, Francesco& Di Lascio, Nicole& Rossi, Chiara& Kusmic, Claudia& Solini, Anna. Ultrasonographic Characterization of the dbdb Mouse: An Animal Model of Metabolic Abnormalities. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183544
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183544
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)