Ultrasonographic Characterization of the dbdb Mouse: An Animal Model of Metabolic Abnormalities
Joint Authors
Kusmic, Claudia
Faita, Francesco
Di Lascio, Nicole
Rossi, Chiara
Solini, Anna
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The availability of an animal model able to reliably mirror organ damage occurring in metabolic diseases is an urgent need.
These models, mostly rodents, have not been fully characterized in terms of cardiovascular, renal, and hepatic ultrasound parameters, and only sparse values can be found in literature.
Aim of this paper is to provide a detailed, noninvasive description of the heart, vessels, liver, and kidneys of the db/db mouse by ultrasound imaging.
Sixteen wild type and thirty-four db/db male mice (11-week-old) were studied.
State-of-the-art ultrasound technology was used to acquire images of cardiovascular, renal, and hepatic districts.
A set of parameters describing function of the selected organs was evaluated.
db/db mice are characterized by systolic and diastolic dysfunction, confirmed by strain analysis.
Abdominal aortic and carotid stiffness do not seem to be increased in diabetic rodents; furthermore, they are characterized by a smaller mean diameter for both vessels.
Renal microcirculation is significantly compromised, while liver steatosis is only slightly higher in db/db mice than in controls.
We offer here for the first time an in vivo detailed ultrasonographic characterization of the db/db mouse, providing a useful tool for a thoughtful choice of the right rodent model for any experimental design.
American Psychological Association (APA)
Faita, Francesco& Di Lascio, Nicole& Rossi, Chiara& Kusmic, Claudia& Solini, Anna. 2018. Ultrasonographic Characterization of the dbdb Mouse: An Animal Model of Metabolic Abnormalities. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183544
Modern Language Association (MLA)
Faita, Francesco…[et al.]. Ultrasonographic Characterization of the dbdb Mouse: An Animal Model of Metabolic Abnormalities. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183544
American Medical Association (AMA)
Faita, Francesco& Di Lascio, Nicole& Rossi, Chiara& Kusmic, Claudia& Solini, Anna. Ultrasonographic Characterization of the dbdb Mouse: An Animal Model of Metabolic Abnormalities. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183544