Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu2+-Induced Oxidation Ex Vivo
المؤلفون المشاركون
Roehrs, Miguel
Somacal, Sabrina
Emanuelli, Tatiana
Conte, Lisiane
Nichelle, Sabrina Marafiga
Rampelotto, Cristine
Robalo, Silvino Sasso
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Lycopene-based medications and supplements have been developed to prevent atherosclerosis, primarily because of their ability to decrease low-density lipoprotein (LDL) oxidation.
Bixin and norbixin are carotenoids found in the seeds of annatto (Bixa orellana) and are colorants widely used by the food industry.
Some studies have already demonstrated that these compounds have antioxidant and antiatherogenic potential in vitro and in animal models, but there is no evidence supporting the effects of their long-term or short-term consumption by humans.
The aim of this study was to evaluate the effects of short-term intake of annatto carotenoids on biochemical and oxidative stress biomarkers as well as on the susceptibility of LDL oxidation in healthy individuals, using lycopene as a positive control.
The effect of daily supplementation (0.05 mg/kg of body weight (b.w.)) with bixin, norbixin, lycopene, or placebo for 7 days was evaluated in a randomized, controlled crossover study in 16 healthy volunteers (8 men and 8 women).
The susceptibility of LDL to Cu2+-induced oxidation ex vivo, biochemical parameters, and oxidative stress biomarkers were evaluated.
No treatment affected biochemical parameters or most oxidative stress biomarkers.
However, bixin reduced the oxidation rate of the LDL lipid moiety (−275%, p<0.1) and nitric oxide metabolites (NOx) (−460%, p<0.1), compared to the placebo group.
Moreover, we observed that the changes in these parameters were positively associated, supporting the hypothesis that bixin decreases the susceptibility of LDL to Cu2+-induced oxidation by decreasing NOx levels, probably by downregulating the inducible nitric oxide synthase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Conte, Lisiane& Somacal, Sabrina& Nichelle, Sabrina Marafiga& Rampelotto, Cristine& Robalo, Silvino Sasso& Roehrs, Miguel…[et al.]. 2019. Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu2+-Induced Oxidation Ex Vivo. Journal of Nutrition and Metabolism،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1183685
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Conte, Lisiane…[et al.]. Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu2+-Induced Oxidation Ex Vivo. Journal of Nutrition and Metabolism No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1183685
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Conte, Lisiane& Somacal, Sabrina& Nichelle, Sabrina Marafiga& Rampelotto, Cristine& Robalo, Silvino Sasso& Roehrs, Miguel…[et al.]. Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu2+-Induced Oxidation Ex Vivo. Journal of Nutrition and Metabolism. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1183685
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183685
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر