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Study of the Dynamic Uptake of Free Drug and Nanostructures for Drug Delivery Based on Bioluminescence Measurements
المؤلفون المشاركون
Fang, Zhongjian
Xu, Houchao
Ji, Xiangjun
Liu, Congbiao
Wang, Kai
Qian, Xiaoqing
Zhou, Wencong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The past two decades have witnessed the great growth of the development of novel drug carriers.
However, the releasing dynamics of drug from drug carriers in vivo and the interactions between cells and drug carriers remain unclear.
In this paper, liposomes were prepared to encapsulate D-luciferin, which was the substrate of luciferase and served as a model drug.
Based on the theoretical calculation of active loading, methods of preparation for liposomes were optimized.
Only when D-luciferin was released from liposomes or taken in by the cells could bioluminescence be produced under the catalysis of luciferase.
Models of multicellular tumor spheroid (MCTS) were built with 4T1-luc cells that expressed luciferase stably.
The kinetic processes of uptake and distribution of free drugs and liposomal drugs were determined with models of cell suspension, monolayer cells, MCTS, and tumor-bearing nude mice.
The technology platform has been demonstrated to be effective for the study of the distribution and kinetic profiles of various liposomes as drug delivery systems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fang, Zhongjian& Xu, Houchao& Ji, Xiangjun& Liu, Congbiao& Wang, Kai& Qian, Xiaoqing…[et al.]. 2017. Study of the Dynamic Uptake of Free Drug and Nanostructures for Drug Delivery Based on Bioluminescence Measurements. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1183694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fang, Zhongjian…[et al.]. Study of the Dynamic Uptake of Free Drug and Nanostructures for Drug Delivery Based on Bioluminescence Measurements. Journal of Nanomaterials No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1183694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fang, Zhongjian& Xu, Houchao& Ji, Xiangjun& Liu, Congbiao& Wang, Kai& Qian, Xiaoqing…[et al.]. Study of the Dynamic Uptake of Free Drug and Nanostructures for Drug Delivery Based on Bioluminescence Measurements. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1183694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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