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Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy
المؤلفون المشاركون
Guillén-Gómez, Elena
Bardají-de-Quixano, Beatriz
Ferrer, Sílvia
Brotons, Carlos
Knepper, Mark A.
Carrascal, Montserrat
Abian, Joaquin
Mas, José M.
Calero, Francesca
Ballarín, José A.
Fernández-Llama, Patricia
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Urinary proteome was analyzed and quantified by tandem mass tag (TMT) labeling followed by bioinformatics analysis to study diabetic nephropathy (DN) pathophysiology and to identify biomarkers of a clinical outcome.
We included type 2 diabetic normotensive non-obese males with (n=9) and without (n=11) incipient DN (microalbuminuria).
Sample collection included blood and urine at baseline (control and DN basal) and, in DN patients, after 3 months of losartan treatment (DN treated).
Urinary proteome analysis identified 166 differentially abundant proteins between controls and DN patients, 27 comparing DN-treated and DN-basal patients, and 182 between DN-treated patients and controls.
The mathematical modeling analysis predicted 80 key proteins involved in DN pathophysiology and 15 in losartan effect, a total of 95 proteins.
Out of these 95, 7 are involved in both processes.
VCAM-1 and neprilysin stand out of these 7 for being differentially expressed in the urinary proteome.
We observed an increase of VCAM-1 urine levels in DN-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria; the latter was confirmed by ELISA.
Our results point to neprilysin and VCAM-1 as potential candidates in DN pathology and treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guillén-Gómez, Elena& Bardají-de-Quixano, Beatriz& Ferrer, Sílvia& Brotons, Carlos& Knepper, Mark A.& Carrascal, Montserrat…[et al.]. 2018. Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1183751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guillén-Gómez, Elena…[et al.]. Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy. Journal of Diabetes Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1183751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guillén-Gómez, Elena& Bardají-de-Quixano, Beatriz& Ferrer, Sílvia& Brotons, Carlos& Knepper, Mark A.& Carrascal, Montserrat…[et al.]. Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1183751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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