Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia
المؤلفون المشاركون
Shirin, Haim
Matalon, Shay
Broide, Efrat
Reifen, Ram
Berkovich, Zipi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-06
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
The role of iron transport proteins in the pathogenesis of anemia in patients with diabetes mellitus (T2DM) is still unclear.
We investigated the expression of duodenal transporter proteins in diabetic patients with and without iron deficiency anemia (IDA).
Methods.
Overall, 39 patients were included: 16 with T2DM and IDA (group A), 11 with T2DM without IDA (group B), and 12 controls (group C).
Duodenal mucosal expression of divalent metal transporter 1 (DMT1), ferroportin 1 (FPN), hephaestin (HEPH), and transferrin receptor 1 (TfR) was evaluated by Western blotting.
Chronic disease activity markers were measured as well.
Results.
FPN expression was increased in group A compared to group B and controls: 1.17 (0.72–1.46), 0.76 (0.53–1.04), and 0.71 (0.64–0.86), respectively (p=0.011).
TfR levels were over expressed in groups A and B compared to controls: 0.39 (0.26–0.61), 0.36 (0.24–0.43), and 0.18 (0.16–0.24), respectively, (p=0.004).
The three groups did not differ significantly with regard to cellular HEPH and DMT1 expression.
The normal CRP and serum ferritin levels, accompanied with normal FPN among diabetic patients without IDA, do not support the association of IDA with chronic inflammatory state.
Conclusion.
In patients with T2DM and IDA, duodenal iron transport protein expression might be dependent on body iron stores rather than by chronic inflammation or diabetes per se.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Broide, Efrat& Reifen, Ram& Matalon, Shay& Berkovich, Zipi& Shirin, Haim. 2018. Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1183870
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Broide, Efrat…[et al.]. Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. Journal of Diabetes Research No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1183870
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Broide, Efrat& Reifen, Ram& Matalon, Shay& Berkovich, Zipi& Shirin, Haim. Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1183870
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183870
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر