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Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia
Joint Authors
Shirin, Haim
Matalon, Shay
Broide, Efrat
Reifen, Ram
Berkovich, Zipi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The role of iron transport proteins in the pathogenesis of anemia in patients with diabetes mellitus (T2DM) is still unclear.
We investigated the expression of duodenal transporter proteins in diabetic patients with and without iron deficiency anemia (IDA).
Methods.
Overall, 39 patients were included: 16 with T2DM and IDA (group A), 11 with T2DM without IDA (group B), and 12 controls (group C).
Duodenal mucosal expression of divalent metal transporter 1 (DMT1), ferroportin 1 (FPN), hephaestin (HEPH), and transferrin receptor 1 (TfR) was evaluated by Western blotting.
Chronic disease activity markers were measured as well.
Results.
FPN expression was increased in group A compared to group B and controls: 1.17 (0.72–1.46), 0.76 (0.53–1.04), and 0.71 (0.64–0.86), respectively (p=0.011).
TfR levels were over expressed in groups A and B compared to controls: 0.39 (0.26–0.61), 0.36 (0.24–0.43), and 0.18 (0.16–0.24), respectively, (p=0.004).
The three groups did not differ significantly with regard to cellular HEPH and DMT1 expression.
The normal CRP and serum ferritin levels, accompanied with normal FPN among diabetic patients without IDA, do not support the association of IDA with chronic inflammatory state.
Conclusion.
In patients with T2DM and IDA, duodenal iron transport protein expression might be dependent on body iron stores rather than by chronic inflammation or diabetes per se.
American Psychological Association (APA)
Broide, Efrat& Reifen, Ram& Matalon, Shay& Berkovich, Zipi& Shirin, Haim. 2018. Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1183870
Modern Language Association (MLA)
Broide, Efrat…[et al.]. Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. Journal of Diabetes Research No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1183870
American Medical Association (AMA)
Broide, Efrat& Reifen, Ram& Matalon, Shay& Berkovich, Zipi& Shirin, Haim. Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1183870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183870