The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse
المؤلفون المشاركون
Fabri, Vanessa A.
Queiroz, Ana C. M.
Mantoan, Henrique
Sanches, Solange M.
Guimarães, Andrea P. G.
Ribeiro, Adriana R. G.
Souza, Ronaldo P.
Maya, Joyce M. L.
Santos, Elizabeth S.
Castro, Fabrício S.
Lima, João P. N. S.
Chen, Michael J.
Baiocchi, Glauco
da Costa, Alexandre A. B. A.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Treatment of advanced uterine cervical cancer has advanced little in the last 15 years.
Although two phase III trials showed survival benefit with the addition of consolidation chemotherapy (CT) after cisplatin-based chemoradiotherapy (RTCT), it is not considered standard of care.
We aimed to evaluate the benefit of consolidation CT compared to no additional treatment in patients treated with RTCT.
Methods.
This is a retrospective study including 186 patients with FIGO stage IB2, IIA2, or IIB to IVB (paraaortic lymph nodes only) uterine cervical cancer who were treated with standard RTCT alone or RTCT followed by consolidation CT.
Overall survival (OS), progression free survival (PFS), and the risk of distant and local relapses were compared between the two treatment groups.
Results.
At 3 years OS was 91% versus 82.3% (p=0.027), PFS 84.3% versus 54.4% (p=0.047), and distant metastasis free survival (DMFS) 80.4% versus 62.5% (p=0.027) in favor of the consolidation CT group.
Multivariate analysis confirmed the benefit of consolidation CT.
There was no difference in locoregional free survival (LRFS).
Positive lymph node was related to a higher risk of distant relapse.
In the lymph node positive subgroup consolidation CT resulted in longer OS (p=0.050), PFS (p=0.014), and DMFS (p=0.022); in the lymph node negative subgroup there was no benefit from consolidation CT.
Conclusions.
Use of consolidation CT resulted in longer OS and PFS, mostly due to control of distant relapses.
Patients at higher risk of distant relapse showed the greatest benefit.
This data generates a hypothesis that could help to better select patients to consolidation CT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fabri, Vanessa A.& Queiroz, Ana C. M.& Mantoan, Henrique& Sanches, Solange M.& Guimarães, Andrea P. G.& Ribeiro, Adriana R. G.…[et al.]. 2019. The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse. Journal of Oncology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183894
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fabri, Vanessa A.…[et al.]. The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse. Journal of Oncology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1183894
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fabri, Vanessa A.& Queiroz, Ana C. M.& Mantoan, Henrique& Sanches, Solange M.& Guimarães, Andrea P. G.& Ribeiro, Adriana R. G.…[et al.]. The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183894
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183894
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر