The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse
Joint Authors
Fabri, Vanessa A.
Queiroz, Ana C. M.
Mantoan, Henrique
Sanches, Solange M.
Guimarães, Andrea P. G.
Ribeiro, Adriana R. G.
Souza, Ronaldo P.
Maya, Joyce M. L.
Santos, Elizabeth S.
Castro, Fabrício S.
Lima, João P. N. S.
Chen, Michael J.
Baiocchi, Glauco
da Costa, Alexandre A. B. A.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Treatment of advanced uterine cervical cancer has advanced little in the last 15 years.
Although two phase III trials showed survival benefit with the addition of consolidation chemotherapy (CT) after cisplatin-based chemoradiotherapy (RTCT), it is not considered standard of care.
We aimed to evaluate the benefit of consolidation CT compared to no additional treatment in patients treated with RTCT.
Methods.
This is a retrospective study including 186 patients with FIGO stage IB2, IIA2, or IIB to IVB (paraaortic lymph nodes only) uterine cervical cancer who were treated with standard RTCT alone or RTCT followed by consolidation CT.
Overall survival (OS), progression free survival (PFS), and the risk of distant and local relapses were compared between the two treatment groups.
Results.
At 3 years OS was 91% versus 82.3% (p=0.027), PFS 84.3% versus 54.4% (p=0.047), and distant metastasis free survival (DMFS) 80.4% versus 62.5% (p=0.027) in favor of the consolidation CT group.
Multivariate analysis confirmed the benefit of consolidation CT.
There was no difference in locoregional free survival (LRFS).
Positive lymph node was related to a higher risk of distant relapse.
In the lymph node positive subgroup consolidation CT resulted in longer OS (p=0.050), PFS (p=0.014), and DMFS (p=0.022); in the lymph node negative subgroup there was no benefit from consolidation CT.
Conclusions.
Use of consolidation CT resulted in longer OS and PFS, mostly due to control of distant relapses.
Patients at higher risk of distant relapse showed the greatest benefit.
This data generates a hypothesis that could help to better select patients to consolidation CT.
American Psychological Association (APA)
Fabri, Vanessa A.& Queiroz, Ana C. M.& Mantoan, Henrique& Sanches, Solange M.& Guimarães, Andrea P. G.& Ribeiro, Adriana R. G.…[et al.]. 2019. The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse. Journal of Oncology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183894
Modern Language Association (MLA)
Fabri, Vanessa A.…[et al.]. The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse. Journal of Oncology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1183894
American Medical Association (AMA)
Fabri, Vanessa A.& Queiroz, Ana C. M.& Mantoan, Henrique& Sanches, Solange M.& Guimarães, Andrea P. G.& Ribeiro, Adriana R. G.…[et al.]. The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183894