Amino Acid Medical Foods Provide a High Dietary Acid Load and Increase Urinary Excretion of Renal Net Acid, Calcium, and Magnesium Compared with Glycomacropeptide Medical Foods in Phenylketonuria
المؤلفون المشاركون
Binkley, Neil
Stroup, Bridget M.
Sawin, Emily A.
Murali, Sangita G.
Hansen, Karen E.
Ney, Denise M.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Skeletal fragility is a complication of phenylketonuria (PKU).
A diet containing amino acids compared with glycomacropeptide reduces bone size and strength in mice.
Objective.
We tested the hypothesis that amino acid medical foods (AA-MF) provide a high dietary acid load, subsequently increasing urinary excretion of renal net acid, calcium, and magnesium, compared to glycomacropeptide medical foods (GMP-MF).
Design.
In a crossover design, 8 participants with PKU (16–35 y) provided food records and 24-hr urine samples after consuming a low-Phe diet in combination with AA-MF and GMP-MF for 1–3 wks.
We calculated potential renal acid load (PRAL) of AA-MF and GMP-MF and determined bone mineral density (BMD) measurements using dual X-ray absorptiometry.
Results.
AA-MF provided 1.5–2.5-fold higher PRAL and resulted in 3-fold greater renal net acid excretion compared to GMP-MF (p=0.002).
Dietary protein, calcium, and magnesium intake were similar.
GMP-MF significantly reduced urinary excretion of calcium by 40% (p=0.012) and magnesium by 30% (p=0.029).
Two participants had low BMD-for-age and trabecular bone scores, indicating microarchitectural degradation.
Urinary calcium with AA-MF negatively correlated with L1–L4 BMD.
Conclusion.
Compared to GMP-MF, AA-MF increase dietary acid load, subsequently increasing urinary calcium and magnesium excretion, and likely contributing to skeletal fragility in PKU.
The trial was registered at clinicaltrials.gov as NCT01428258.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stroup, Bridget M.& Sawin, Emily A.& Murali, Sangita G.& Binkley, Neil& Hansen, Karen E.& Ney, Denise M.. 2017. Amino Acid Medical Foods Provide a High Dietary Acid Load and Increase Urinary Excretion of Renal Net Acid, Calcium, and Magnesium Compared with Glycomacropeptide Medical Foods in Phenylketonuria. Journal of Nutrition and Metabolism،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1183910
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stroup, Bridget M.…[et al.]. Amino Acid Medical Foods Provide a High Dietary Acid Load and Increase Urinary Excretion of Renal Net Acid, Calcium, and Magnesium Compared with Glycomacropeptide Medical Foods in Phenylketonuria. Journal of Nutrition and Metabolism No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1183910
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stroup, Bridget M.& Sawin, Emily A.& Murali, Sangita G.& Binkley, Neil& Hansen, Karen E.& Ney, Denise M.. Amino Acid Medical Foods Provide a High Dietary Acid Load and Increase Urinary Excretion of Renal Net Acid, Calcium, and Magnesium Compared with Glycomacropeptide Medical Foods in Phenylketonuria. Journal of Nutrition and Metabolism. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1183910
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183910
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر